反应详情

Mix equimolar parts of β-(2-naphthyl)-β-alanine methyl ester, hydrochloride and 2-acetylthiomethyl-3-phenylpropanoic acid with 1.2 equivalents each of EDC, triethylamine and HOBT in DMF and stir overnight. Evaporate the solvent, partition between EtOAc and water, and concentrate the organic layer. Separate on silica using ether/hexane and crystallize from acetone/hexane to obtain the title compound, m.p. 133°-135° C.

1. customEvaporate the solvent
2. custompartition between EtOAc and water
3. concentrationconcentrate the organic layer
4. customSeparate on silica
5. customcrystallize from acetone/hexane