反应详情

A mixture of 4.58 g. of N-[3-(1H-imidazol-1-yl)propyl]benzamide, 40 ml. of dimethylformamide, and 0.96 g. of 50% sodium hydride in oil was stirred for 2 hours and 2.62 g. of benzyl bromide was added. The mixture was stirred for 24 hours, concentrated to remove the dimethyl formamide, diluted with water and methylene chloride, and the layers separated. The organic layer was washed with water, dried over magnesium sulfate, and concentrated. The oil was twice washed with hexane and again concentrated. The desired product was obtained as an oil.

1. additionA mixture of 4.58 g
2. concentrationconcentrated
3. customto remove the dimethyl formamide
4. additiondiluted with water and methylene chloride
5. customthe layers separated
6. washThe organic layer was washed with water
7. dry with materialdried over magnesium sulfate
8. concentrationconcentrated
9. washThe oil was twice washed with hexane
10. concentrationagain concentrated