Water → Ethyl (2-amino-3-benzoylphenyl)acetate

HRID 1589205노트

반응식

HRID 1589205 반응식
[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([OH:19])=[O:18].[Na].[CH2:21](I)[CH3:22].O>CN(C)C=O>[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([O:19][CH2:21][CH3:22])=[O:18]

참가 물질

6

반응물 4

HCID 962WaterHCID 2136AmfenacHCID 6340IodoethaneHCID 5360545Sodium

생성물 1

HCID 12901249Ethyl (2-amino-3-benzoylphenyl)acetate수율 66.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 2.5 g (0.009 mole) of (2-amino-3-benzoylphenyl)acetic acid, sodium salt in 25 ml of dry dimethylformamide was treated with 5 g of ethyl iodide (0.035 mole) and stirred with a magnetic stirrer at room temperature for 2 hours. The reaction mixture was then added to water and extracted several times with ethyl ether. The ether extracts, after being washed with water, were dried over sodium sulfate and stripped under vacuum to leave a yellow solid residue. This residue was recrystallized from absolute ethyl alcohol to give 1.7 g (61%) of the titled compound as yellow needles, m.p. 77°-78° C.

후처리

  1. extractionextracted several times with ethyl ether
  2. washafter being washed with water
  3. dry with materialwere dried over sodium sulfate
  4. customto leave a yellow solid residue
  5. customThis residue was recrystallized from absolute ethyl alcohol

출처 및 근거

ORD 기록
ord-0d40a66bf26b472db1505214e1ed342a
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04568695

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