Hydrochloric Acid → HCID 14065730, compound

HRID 1589595Notes

Reaction equation

HRID 1589595 reaction equation
[F:1][C:2]([F:17])([O:6][C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([O:12]C)=[O:11])[CH:3]([F:5])[Cl:4].[OH-].[K+].O.Cl>O1CCCC1>[F:1][C:2]([F:17])([O:6][C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([OH:12])=[O:11])[CH:3]([F:5])[Cl:4]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 20245388HCID 20245388, compound

Product 1

HCID 14065730HCID 14065730, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
95 °C

Procedure

40 Parts by weight of methyl 3-(1',1',2'-trifluoro-2'-chloroethoxy)-benzoate, in a mixture of 8.4 parts by weight of potassium hydroxide, 100 parts by weight of water and 5 parts by weight of tetrahydrofuran, are stirred for 15 minutes at 95° C. The resulting solution is acidified with concentrated hydrochloric acid and the precipitate formed is filtered off and dried; 35 parts of 3-(1',1',2'-trifluoro-2'-chloroethoxy)benzoic acid of melting point 79°-85° C. are obtained.

Workup

  1. customthe precipitate formed
  2. filtrationis filtered off
  3. customdried

Sources & evidence

ORD record
ord-c00542e0e41249ecb8c15ac62ec62155
Source dataset
uspto-grants-1986_02
Patent number
USRE032087

Reaction notes

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