Hydroxide → HCID 22913067, compound

HRID 1589900Notes

Reaction equation

[C:1](OCC)(=O)[CH2:2][C:3]([CH3:5])=O.[C:10]([CH2:12][C:13]([NH2:15])=O)#[N:11].[OH-]>>[C:10]([CH:12]1[C:3]([CH3:5])=[CH:2][CH2:1][NH:15][CH2:13]1)#[N:11]

Participants

Reactant 3

HCID 961Hydroxide

HCID 7898Cyanoacetamide

HCID 8868Ethyl Acetoacetate

Product 1

HCID 22913067HCID 22913067, compound

Procedure

reacting ethyl acetoacetate with cyanoacetamide and a hydroxide of an alkali metal, in the presence of an organic solvent, at a temperature of from 60° C. to 80° C., for 1 to 4 hours, to produce 3-cyano-2,6-dihydro-4-methylpyridine;

Sources & evidence

ORD record: ord-3192a80db05540f784512e4e32274286
Source dataset: uspto-grants-1993_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05200522

Reaction notes

Loading…