反应详情

温度

80 °C

The ester from Step 1 (51.3 g) was hydrolysed using 325 mL THF, 600 mL MeOH and 325 mL of 1N LiOH solution. The mixture was heated to 80° C. for 3 hours, then cooled, acidified with 1N HCl and extracted with 3×200 mL EtOAc. The organic phase was washed with H2O (2×150 mL) and dried (MgSO4). After removal of the solvent the title compound was obtained as a white solid, m.p. 190°-191° C.

1. temperaturecooled
2. extractionextracted with 3×200 mL EtOAc
3. washThe organic phase was washed with H2O (2×150 mL)
4. dry with materialdried (MgSO4)
5. customAfter removal of the solvent the title compound
6. customwas obtained as a white solid, m.p. 190°-191° C.