反应详情

0,6 M of n-butyllithium are added at -10° to 0,6 M of diisopropylamin in 600 ml THF. The mixture is cooled to -70°, 0,6 M of 2,6-difluoropyridin are added and after stirring for 15 minutes 0,6 M of trimethylborate are added at the same temperature. The mixture is allowed to warm up to -30°. Then the borate ester is hydrolysed with dilute HCl, the product extracted with ether, washed, dried and the solvent removed. Thus, 2,6-difluoro-pyridine-3-boronic acid is obtained.

1. temperatureThe mixture is cooled to -70°
2. additionare added at the same temperature
3. temperatureto warm up to -30°
4. extractionthe product extracted with ether
5. washwashed
6. customdried
7. customthe solvent removed