Hydrogen Peroxide → 6-Carbamoyl-1-(1-imidazolyl)-3,4-dihydronaphthalene

HRID 1591076Notes

Reaction equation

HRID 1591076 reaction equation
C(=O)([O-])[O-:2].[K+].[K+].OO.[C:9]([C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[C:17]([N:21]1[CH:25]=[CH:24][N:23]=[CH:22]1)=[CH:16][CH2:15][CH2:14]2)#[N:10].O>CS(C)=O.C(Cl)Cl>[C:9]([C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[C:17]([N:21]1[CH:25]=[CH:24][N:23]=[CH:22]1)=[CH:16][CH2:15][CH2:14]2)(=[O:2])[NH2:10]

Participants

7

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 11430Potassium CarbonateHCID 98373925-(1H-imidazol-1-yl)-7,8-dihydronaphthalene-2-carbonitrile

Product 1

HCID 197664926-Carbamoyl-1-(1-imidazolyl)-3,4-dihydronaphthalene

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 6344DichloromethaneSolvent

Procedure

Potassium carbonate and 30% aqueous H2O2 solution are added several times, within a period of 24 hours, to 6-cyano-1-(1-imidazolyl)-3,4-dihydronaphthalene (Example 1) in DMSO and CH2Cl2. Finally, water is added and the solid is filtered off, yielding the title compound.

Workup

  1. filtrationthe solid is filtered off

Sources & evidence

ORD record
ord-1efc13136af34c82890a9eb275e816b3
Source dataset
uspto-grants-1993_04
Patent number
US05206256

Reaction notes

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