Tetrahydrofuran → HCID 67854827, compound

HRID 1591378Notes

Reaction equation

HRID 1591378 reaction equation
C([N:3]([CH2:6]C)[CH2:4][CH3:5])C.[OH:8][C:9]1[CH:25]=[CH:24][C:12]([C:13]([C:15]2[CH:20]=[CH:19][C:18]([N:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=2)=[O:14])=[CH:11][CH:10]=1.[C:26](OCCN=C=O)(=[O:30])[C:27]([CH3:29])=[CH2:28].[O:37]1CCCC1>C1(C)C=CC=CC=1>[CH3:22][N:21]([CH3:23])[C:18]1[CH:19]=[CH:20][C:15]([C:13](=[O:14])[C:12]2[CH:24]=[CH:25][C:9]([O:8][C:6](=[O:37])[NH:3][CH2:4][CH2:5][C:26](=[O:30])[C:27]([CH3:29])=[CH2:28])=[CH:10][CH:11]=2)=[CH:16][CH:17]=1

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 354092-Isocyanatoethyl methacrylateHCID 14205141[4-(Dimethylamino)phenyl](4-hydroxyphenyl)methanone

Product 1

HCID 67854827HCID 67854827, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
30 °C

Procedure

0.35 g of triethylamine, dissolved in 13 ml of tetrahydrofuran, was added dropwise at from 15° to 20° C. to a solution of 11.6 g (50 millimoles) of 4-hydroxy-4'-dimethylaminobenzophenone and 8.6 g (55 millimoles) of isocyanatoethyl methacrylate in 50 ml of toluene. The temperature was found to increase slightly to about 30° C. After stirring had been carried out for 10 hours at room temperature, the precipitated crystals were filtered off under suction, washed with toluene and recrystallized from isopropanol.

Workup

  1. filtrationthe precipitated crystals were filtered off under suction
  2. washwashed with toluene
  3. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-d9bb27984cd74919be367a27a6b4b1bc
Source dataset
uspto-grants-1993_04
Patent number
US05206417

Reaction notes

Loading…