Hydrochloric Acid → HCID 67139686, compound

HRID 1591961Notes

Reaction equation

HRID 1591961 reaction equation
Cl.[N+:2]([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH2:8][NH2:9])([O-:4])=[O:3].C([O-])(O)=O.[Na+].[S:18](N)([NH2:21])(=[O:20])=[O:19].Cl>O>[N+:2]([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH2:8][NH:9][S:18]([NH2:21])(=[O:20])=[O:19])([O-:4])=[O:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 82267SulfamideHCID 516892Sodium BicarbonateHCID 2724030Benzenemethanamine, 3-nitro-, hydrochloride (1:1)

Product 1

HCID 67139686HCID 67139686, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 3-nitrobenzylamine hydrochloride, (1.89 g, 10.0 mmol) in water (10 mL) is treated with NaHCO3 (840 mg, 10.0 mmol) and sulfamide, (960 mg, 10.0 mmol). The mixture is heated at reflux for 5 h. The cooled mixture is acidified to pH 2 with 1N aqueous HCl and the precipitate is filtered, washed with water and dried under vacuum at 50° C. to afford 3-nitrobenzyl sulfamide as a tan solid: [M−1]−=230.

Workup

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 5 h
  3. filtrationthe precipitate is filtered
  4. washwashed with water
  5. customdried under vacuum at 50° C.

Sources & evidence

ORD record
ord-9c2f30689a7f46ffaf28a3e749e00998
Source dataset
uspto-grants-2007_11
Patent number
US07291635B2

Reaction notes

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