m-Chloroperbenzoic acid → HCID 69025582, compound

HRID 1594415Notes

Reaction equation

HRID 1594415 reaction equation
CS[C:3]1[N:7]=[C:6]([CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[S:5][N:4]=1.Cl[C:15]1C=C(C=CC=1)C(OO)=O.[S:25]([O-:28])(O)=[O:26].[Na+]>C(Cl)(Cl)Cl>[CH3:15][S:25]([C:3]1[N:7]=[C:6]([CH:8]2[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]2)[S:5][N:4]=1)(=[O:28])=[O:26]

Participants

5

Reactant 3

HCID 70297m-Chloroperbenzoic acidHCID 23665763Sodium BisulfiteHCID 58610441HCID 58610441, compound

Product 1

HCID 69025582HCID 69025582, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

370 mg of 3-methylthio-5-cyclohexyl-1,2,4-thiadiazole was dissolved in 8 ml of chloroform, 1.12 g of 3-chloroperoxybenzoic acid (content>65%) was added thereto, and the reaction mixture was stirred for 7 hours under ice-cooling. Then, the reaction mixture was added to saturated sodium hydrogensulfite aqueous solution, and separated. The organic layer was washed with sodium hydrogencarbonate aqueous solution, dried over anhydrous sodium sulfate, concentrated to give 444 mg of 3-methylsulfonyl-5-cyclohexyl-1,2,4-thiadiazole.

Workup

  1. temperaturecooling
  2. customseparated
  3. washThe organic layer was washed with sodium hydrogencarbonate aqueous solution
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-7dec8c81a9e843828a86e66223bbc045
Source dataset
uspto-grants-2007_11
Patent number
US07301032B2

Reaction notes

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