m-Chloroperbenzoic acid → HCID 69025990, compound

HRID 1594417Notes

Reaction equation

HRID 1594417 reaction equation
CS[C:3]1[N:7]=[C:6]([CH:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)[S:5][N:4]=1.Cl[C:14]1C=C(C=CC=1)C(OO)=O.[S:24]([O-:27])(O)=[O:25].[Na+]>C(Cl)(Cl)Cl>[CH3:14][S:24]([C:3]1[N:7]=[C:6]([CH:8]2[CH2:9][CH2:10][CH2:11][CH2:12]2)[S:5][N:4]=1)(=[O:27])=[O:25]

Participants

5

Reactant 3

HCID 70297m-Chloroperbenzoic acidHCID 23665763Sodium BisulfiteHCID 58610423HCID 58610423, compound

Product 1

HCID 69025990HCID 69025990, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

710 mg of 3-methylthio-5-cyclopentyl-1,2,4-thiadiazole was dissolved in 15 ml of chloroform, 1.89 g of 3-chloroperoxybenzoic acid (content>65%) was added thereto, and the reaction mixture was stirred for 30 minutes under ice-cooling and for 3.5 hours at room temperature. Then, the reaction mixture was added to saturated sodium hydrogensulfite aqueous solution, and separated. The organic layer was washed with sodium hydrogencarbonate aqueous solution, dried over anhydrous sodium sulfate, concentrated to give 804 mg of 3-methylsulfonyl-5-cyclopentyl-1,2,4-thiadiazole.

Workup

  1. customseparated
  2. washThe organic layer was washed with sodium hydrogencarbonate aqueous solution
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-90615331f9b64190b68cd7443cc9c460
Source dataset
uspto-grants-2007_11
Patent number
US07301032B2

Reaction notes

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