1-Bromo-3-chloropropane → HCID 12146432, compound

HRID 1595162Notes

Reaction equation

HRID 1595162 reaction equation
[CH3:1][N:2]1[C:11]2[C:10](=[O:12])[CH2:9][CH2:8][NH:7][C:6](=[O:13])[C:5]=2[C:4]([CH3:14])=[CH:3]1.CC(C)([O-])C.[K+].Br[CH2:22][CH2:23][CH2:24][Cl:25]>C1COCC1>[Cl:25][CH2:24][CH2:23][CH2:22][N:7]1[CH2:8][CH2:9][C:10](=[O:12])[C:11]2[N:2]([CH3:1])[CH:3]=[C:4]([CH3:14])[C:5]=2[C:6]1=[O:13]

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 12044319HCID 12044319, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 12146432HCID 12146432, compoundYield 50.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Using Compound 12 (0.96 g, 5 mmole), potassium t-butoxide (1.12 g, 10 mmole), 1-bromo-3-chloropropane (3.46 g, 22 mmole) and THF (50 ml), the title compound (676 mg) was obtained in a similar manner as in Preparation Example 6 (yield: 50%).

Sources & evidence

ORD record
ord-3feb865341974c49925e957394e13ff3
Source dataset
uspto-grants-2001_09
Patent number
US06288056B1

Reaction notes

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