Sodium Iodide → HCID 12044320, compound

HRID 1595163Notes

Reaction equation

HRID 1595163 reaction equation
Cl[CH2:2][CH2:3][CH2:4][N:5]1[CH2:11][CH2:10][C:9](=[O:12])[C:8]2[N:13]([CH3:17])[CH:14]=[C:15]([CH3:16])[C:7]=2[C:6]1=[O:18].[F:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[CH:22][CH:21]=1.C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>C(#N)C>[F:19][C:20]1[CH:21]=[CH:22][C:23]([N:26]2[CH2:31][CH2:30][N:29]([CH2:2][CH2:3][CH2:4][N:5]3[CH2:11][CH2:10][C:9](=[O:12])[C:8]4[N:13]([CH3:17])[CH:14]=[C:15]([CH3:16])[C:7]=4[C:6]3=[O:18])[CH2:28][CH2:27]2)=[CH:24][CH:25]=1

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 752601-(4-Fluorophenyl)piperazineHCID 12146432HCID 12146432, compound

Product 1

HCID 12044320HCID 12044320, compoundYield 80.2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Using Compound 13 (557 mg, 2 mmole), 1-(4-fluorophenyl)piperazine (541 mg, 3 mmole), potassium carbonate (415 mg, 3 mmole), sodium iodide (600 mg, 4 mmole) and acetonitrile (30 ml), the title compound (662 mg) was obtained in a similar manner as in Preparation Example 8 (yield: 80%).

Sources & evidence

ORD record
ord-12c77a9c90f94ee3b9924b5947aada0b
Source dataset
uspto-grants-2001_09
Patent number
US06288056B1

Reaction notes

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