反应详情

1-(3,4-Dichlorobenzyl)-4-oxo-4,5,6,7-tetrahydroindole-2-carboxylic acid (1.32 g) and benzyl bromide (0.68 g) was stirred in DMF (10 mL) over potassium carbonate (0.48 g) for 18 hours. The DMF was removed in vacuo and the residue was dissolved in ethyl acetate (50 mL). The organic solution was washed with 2M HCl and dried over MgSO4. The solvents were removed in vacuo to afford the title compound as a pale solid (1.63 g, 97%), NMR d(CDCl3) 2.20 (2H, di), 2.50 (2H, t), 2.70 (2H, t), 5.21 (2H, m), 5.55 (2H, s), 6.80 (1H, d), 7.10 (1H,s), 7.35(6H, s), 7.50(1H, s); M/z(+)430, 428 (M+).

1. customThe DMF was removed in vacuo
2. dissolutionthe residue was dissolved in ethyl acetate (50 mL)
3. washThe organic solution was washed with 2M HCl
4. dry with materialdried over MgSO4
5. customThe solvents were removed in vacuo