Triethylamine → HCID 178472083, compound

HRID 1596564Notes

Reaction equation

C([N:3](CC)CC)C.[C:8]([O:12][C:13]([NH:15][C:16](=[N:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])SC)=[O:14])([CH3:11])([CH3:10])[CH3:9].N[C:28]1[CH:29]=[C:30]([S:34]([NH:37][C:38]2[CH:39]=[C:40]([CH:44]([NH:51][C:52](=[O:63])[CH:53]([C:55]3[C:60]([CH3:61])=[CH:59][C:58]([CH3:62])=[CH:57][CH:56]=3)[CH3:54])[CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])[CH:41]=[CH:42][CH:43]=2)(=[O:36])=[O:35])[CH:31]=[CH:32][CH:33]=1.C(OCC)(=O)C>CN(C=O)C>[CH3:54][CH:53]([C:55]1[C:60]([CH3:61])=[CH:59][C:58]([CH3:62])=[CH:57][CH:56]=1)[C:52]([NH:51][CH:44]([C:40]1[CH:41]=[CH:42][CH:43]=[C:38]([N:37]([NH:3][C:16]([NH:15][C:13]([O:12][C:8]([CH3:9])([CH3:10])[CH3:11])=[O:14])=[N:19][C:20]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:21])[S:34]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:28][CH:29]=2)(=[O:36])=[O:35])[CH:39]=1)[CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])=[O:63]

Participants

Conditions

Temperature: 0 °C

Procedure

0.12 ml of triethylamine, 195 mg of 1,3-bis(t-butoxycarbonyl)-2-methyl-2-thiopseudourea and 132 mg of mercuric chloride were added at 0° C. to a solution of 250 mg of (3d) in 10 ml of DMF. The reaction mixture was stirred at 0° C. for 30 min and at room temperature for 2.5 h. 15 ml of ethyl acetate were added, and it was stirred for 30 min before the precipitate was removed by filtration. The solution was concentrated and reused without purification.

Workup

stirringit was stirred for 30 min before the precipitate
customwas removed by filtration
concentrationThe solution was concentrated
customreused without purification

Sources & evidence

ORD record: ord-748a74f9ab6243279e26673d9d768100
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06291503B1

Reaction notes

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