反应详情

2-Bromoethyl methyl ether (3.2 ml, 33 mmol) was added dropwise to a solution of 7-benzyloxy-3,4-dihydroquinazolin-4-thione (7.4 g, 28 mmol), (prepared as described for the starting material in Example 8), in DMF (275 ml) containing potassium carbonate (4.6 g, 33 mmol). After stirring for 4 hours, water was added and the precipitate was collected by filtration, washed with water, and dried under vacuum to give 7-benzyloxy4-(2-methoxyethylsulphanyl)quinazoline (8 g, 89%).

1. custom(prepared
2. filtrationthe precipitate was collected by filtration
3. washwashed with water
4. customdried under vacuum