HRID1597625

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7972

4-Methylmorpholine

C5H11NO

结构：CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F

HCID151348

Tri(dimethylamino)benzotriazol-1-yloxyphosphonium hexafluorophosphate

C12H22F6N6OP2

HCID70072736

未命名化合物

结构：CC(C)(C)OC(=O)[C@H](CNC(=O)CN)NS(=O)(=O)c1ccccc1

HCID86754467

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)c1nc(CCCC(=O)NCC(=O)NC[C@H](NS(=O)(=O)c2ccccc2)C(=O)OC(C)(C)C)ccc1N

HCID86754476

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Acid 5-5 (144 mg, 0.51 mmol), amine 5-7 (202 mg, 0.56 mmol), NMM (226 μL, 2.1 mmol) and BOP (241 mg, 0.77 mmol) were combined in 2.6 mL DMF. Mter stirring overnight the solvent was evaporated, the residue was dissolved in EtOAc, washed with water, sat. NaHCO3, 5% KHSO4, and brine, dried (MgSO4), filtered and concentrated. Flash chromatography (silica, 10% CHCl3/EtOAc) provided 5-8 as an off-white glass.

WORKUP

后处理

customwas evaporated
dissolutionthe residue was dissolved in EtOAc
washwashed with water, sat. NaHCO3, 5% KHSO4, and brine
dry with materialdried (MgSO4)
filtrationfiltered
concentrationconcentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-87f7518d5bda45f5b29085654c5d319b
来源数据集: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06294549B1
来源说明: uspto-grants-2001_09

反应 SMILES

[C:1]([C:8]1[C:13]([NH2:14])=[CH:12][CH:11]=[C:10]([CH2:15][CH2:16][CH2:17][C:18]([OH:20])=O)[N:9]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[C:21]([O:25][C:26](=[O:44])[C@@H:27]([NH:34][S:35]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)(=[O:37])=[O:36])[CH2:28][NH:29][C:30](=[O:33])[CH2:31][NH2:32])([CH3:24])([CH3:23])[CH3:22].CN1CCOCC1.F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1>CN(C=O)C>[C:21]([O:25][C:26](=[O:44])[C@@H:27]([NH:34][S:35]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)(=[O:37])=[O:36])[CH2:28][NH:29][C:30](=[O:33])[CH2:31][NH:32][C:18](=[O:20])[CH2:17][CH2:16][CH2:15][C:10]1[N:9]=[C:8]([C:1]([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2])[C:13]([NH2:14])=[CH:12][CH:11]=1)([CH3:24])([CH3:22])[CH3:23]