1-Naphthoic acid → HCID 22884139, compound

HRID 1598468Notes

Reaction equation

HRID 1598468 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][C@@H:9]1[CH2:14][CH2:15][CH2:16][O:17][CH3:18])=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:19]1([C:29](O)=[O:30])[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][CH:20]=1.C1C=CC2N(O)N=NC=2C=1.CCN=C=NCCCN(C)C.Cl>CN(C=O)C>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:29]([C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]=[CH:21][CH:20]=2)=[O:30])[CH2:10][C@@H:9]1[CH2:14][CH2:15][CH2:16][O:17][CH3:18])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 68471-Naphthoic acidHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 22884140HCID 22884140, compound

Product 1

HCID 22884139HCID 22884139, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared according to the procedure described for Example 1, Step A except using 1-tert-butoxycarbonyl-2(S)-(3-methoxypropyl)piperazine (0.215 g, 0.832 mmol), naphthalene-1-carboxylic acid (0.143 g, 0.83 mmol), HOBT (0.128 g, 0.83 mmol), EDC.HCl (0.160 g, 0.83 mmol) in DMF (5 mL). The title compound was obtained as an oil (0.310 g).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-3fc888475a96402d96a86d345e26d584
Source dataset
uspto-grants-1998_04
Patent number
US05736539

Reaction notes

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