1-Hydroxybenzotriazole → HCID 22884173, compound

HRID 1598476Notes

Reaction equation

HRID 1598476 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:13][CH2:14][CH2:15][CH3:16])[C:10]([OH:12])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].CCN=C=NCCCN(C)C.Cl.C(OC(OCC)C[NH:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)C.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C>[CH2:35]([NH:34][C:10](=[O:12])[C@H:9]([NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH2:13][CH2:14][CH2:15][CH3:16])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

Participants

6

Reactant 4

HCID 757711-HydroxybenzotriazoleHCID 521961(Benzylamino)acetaldehyde diethyl acetalHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2733747N-tert-Butoxycarbonyl-L-norleucine

Product 1

HCID 22884173HCID 22884173, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared according to the procedure described in Example 1, Step A except using 2(S)-t-butoxycarbonylaminohexanoic acid (1.98 g, 8.57 mmol), EDC.HCl (1.96 g, 10.28 mmol), N-benzyl 2-aminoacetaldehyde diethyl acetal (1.91 g, 8.57 mmol), HOBT (1.15 g, 8.57 mmol) in DMF. The title compound was obtained as a yellow oil.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-5b32dfcae3b54c93b092536bbb58e13b
Source dataset
uspto-grants-1998_04
Patent number
US05736539

Reaction notes

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