反应详情

in 30 ml of carbon disulfide was suspended 1.60 g of anhydrous aluminum chloride, and to the suspension were added under ice cooling 580 mg of dimethyl succinic anhydride and then 790 mg of 2-(1,3-isoindolinedion-2-yl)indane. The mixture was stirred at 0° C. to room temperature for 3 hours and then refluxed under heating for 4 hours. The reaction mixture was poured into ice water, and hydrochloric acid was added thereto. The mixture was extracted with dichloromethane-tetrahydrofuran (3:1), the extract was dried, and then the solvent was removed. The resulting crystals were washed with ethyl acetate and dried to obtain 580 mg of 2-(1,3-isoindolinedion-2-yl)-5-(3-carboxy-3,3-dimethylpropionyl)indane.

1. temperaturerefluxed
2. temperatureunder heating for 4 hours
3. additionwas added
4. extractionThe mixture was extracted with dichloromethane-tetrahydrofuran (3:1)
5. customthe extract was dried
6. customthe solvent was removed
7. washThe resulting crystals were washed with ethyl acetate
8. customdried