N-Hydroxyphthalimide → Phthalimide

HRID 1599805Notes

Reaction equation

HRID 1599805 reaction equation
O[N:2]1[C:6](=[O:7])[C:5]2=[CH:8][CH:9]=[CH:10][CH:11]=[C:4]2[C:3]1=[O:12].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CCOC(/N=N/C(OCC)=O)=O>>[C:3]1(=[O:12])[C:4]2[C:5](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:7])[NH:2]1

Participants

4

Reactant 3

HCID 10665N-HydroxyphthalimideHCID 11776TriphenylphosphineHCID 5462977Diethyl azodicarboxylate

Product 1

HCID 6809Phthalimide

Procedure

contacting the product of (iv) with N-hydroxyphthalimide, triphenylphosphine and diethylazodicarboxylate to obtain a stereoisomer of 2-(1-(t-Boc-amino)methyl)-2-(2-nitro-1H-imidazol-1-yl)ethoxy)1H-isoindole-1,3(2H)-dione;

Sources & evidence

ORD record
ord-21b6bb5a6d13481892549859cdacb1ad
Source dataset
uspto-grants-1998_04
Patent number
US05741912

Reaction notes

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