Thiophenol → 1-(Phenylsulfanyl)-4-pyridin-3-ylbutan-2-ol

HRID 1600954Notes

Reaction equation

HRID 1600954 reaction equation
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[O:10]1[CH2:12][CH:11]1[CH2:13][CH2:14][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1>CN(C)C=O>[C:1]1([S:7][CH2:12][CH:11]([OH:10])[CH2:13][CH2:14][C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 7969ThiophenolHCID 24758Sodium hydrideHCID 10877288HCID 10877288, compound

Product 1

HCID 224653391-(Phenylsulfanyl)-4-pyridin-3-ylbutan-2-olYield 76.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared according to the method described in Example 1a) from thiophenol (0.142 g), sodium hydride (0.062 g) and 3-(2-oxiranylethyl)pyridine (0.150 g) in dimethylformamide at room temperature to give the title compound as an oil (0.200 g).

Workup

  1. customPrepared
  2. customat room temperature

Sources & evidence

ORD record
ord-f85d8bb5ed7f4a6e81fecacf33db5f8f
Source dataset
uspto-grants-1999_11
Patent number
US05977105

Reaction notes

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