p-Bromoacetophenone → 4'-Piperidinoacetophenone

HRID 1601644Notes

Reaction equation

HRID 1601644 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>>[N:11]1([C:2]2[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 7466p-BromoacetophenoneHCID 8082Piperidine

Product 1

HCID 825614'-Piperidinoacetophenone

Procedure

without solvents (e.g. B. G. Kresze and H. Goetz, Chern. Berichte 90, 2161, 2174 (1957)), reaction of p-bromoacetophenone with piperidine under reflux with 19% yields of 1-(4-piperidinophenyl)ethanone; or

Workup

  1. temperatureunder reflux with 19%

Sources & evidence

ORD record
ord-c7d294b0d9d0460286571eac7c799da9
Source dataset
uspto-grants-1999_11
Patent number
US05977357

Reaction notes

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