Methanesulfonic Acid → 2-[(Methanesulfonyl)oxy]butane-1,4-diyl dimethanesulfonate

Temperature

2.5 °C

A solution of 18.1 ml of methanesulphonic acid in 45 ml of ethyl acetate was added dropwise within 2 hours under argon to a solution, cooled to 0-5° C., of 7.96 g of S-1,2,4-butanetriol and 33.5 ml of triethylamine in 90 ml of ethyl acetate. The white suspension was stirred at 0-5° C. for a further 2 hours and thereafter the suspension was filtered and the yellow filtrate was washed in succession with 75 ml of 1N hydrochloric acid, 75 ml of saturated NaHCO3 solution and 75ml of saturated NaCl solution. The organic phase was dried over Na2SO4, filtered and the filtrate was concentrated. 21.79 g of yellow oil were obtained.

1. filtrationthe suspension was filtered
2. washthe yellow filtrate was washed in succession with 75 ml of 1N hydrochloric acid, 75 ml of saturated NaHCO3 solution and 75ml of saturated NaCl solution
3. dry with materialThe organic phase was dried over Na2SO4
4. filtrationfiltered
5. concentrationthe filtrate was concentrated

ORD record

ord-d56c5b2b22de4731a6d947cd325624b1

Source dataset

uspto-grants-1999_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05977381