Tetrahydrofuran → HCID 21832300, compound

HRID 1601755Notes

Reaction equation

HRID 1601755 reaction equation
O1CCCC1.[F:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:8]=1[C:9](Cl)=[O:10].[F:17][C:18]([F:32])([F:31])[O:19][C:20]1[CH:30]=[CH:29][C:23]([O:24][CH2:25][CH2:26][CH2:27][NH2:28])=[CH:22][CH:21]=1>C(N(CC)CC)C>[F:17][C:18]([F:31])([F:32])[O:19][C:20]1[CH:30]=[CH:29][C:23]([O:24][CH2:25][CH2:26][CH2:27][NH:28][C:9](=[O:10])[C:8]2[C:7]([F:6])=[CH:15][CH:14]=[CH:13][C:12]=2[F:16])=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 8028Tetrahydrofuran2×HCID 874382,6-Difluorobenzoyl chlorideHCID 218322893-[4-(Trifluoromethoxy)phenoxy]propan-1-amine

Product 1

HCID 21832300HCID 21832300, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A tetrahydrofuran (5 ml) solution of 2,6-difluorobenzoyl chloride (0.88 g) was added dropwise under ice-cooling and stirring to a tetrahydrofuran (20 ml) solution of 3-(4-trifluoromethoxyphenoxy)propylamine (1.18 g) and triethylamine (0.50 g) and the mixture was further stirred at room temperature for one hour.

Workup

  1. temperaturecooling

Sources & evidence

ORD record
ord-941f3bec288a492a93808c7a05436b7f
Source dataset
uspto-grants-1999_11
Patent number
US05977410

Reaction notes

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