反应详情

温度

160 °C

A mixture of compound 19 (1.9 g, 6.64 mmol) phenol (42 ml) and HI (35 ml) was refluxed at 160° C. for 8 hour and the reaction mixture was poured into aqueous NaHSO3 solution. The resulting yellow precipitate, was collected, purified by silica gel column chromatography (CH2Cl2 --MeOH, 4:1), and crystallized from methanol to give pale yellow needles 20, 1.41 g (5.78 mmol, 87%).

1. customThe resulting yellow precipitate, was collected
2. custompurified by silica gel column chromatography (CH2Cl2 --MeOH, 4:1)
3. customcrystallized from methanol