Hydrochloric Acid → Donepezil Hydrochloride

HRID 1602814Notes

Reaction equation

HRID 1602814 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:21][CH2:20][N:19]([CH2:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH2:18][CH2:17]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[ClH:29]>C(OCC)(=O)C.C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:17][CH2:18][N:19]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:20][CH2:21]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[ClH:29]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 3152Donepezil

Product 1

HCID 5741Donepezil Hydrochloride

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

0.3 g of Donepezil was dissolved in 3 ml of ethyl acetate under heating. Under stirring at room temperature, 0.79 ml of 10%-hydrogen chloride in ethanol solution was added. Filtration of the crystals and drying at 85° C. for 3 hours, then at 70° C. for 16 hours afforded 0.3g of the title compound.

Workup

  1. temperatureunder heating
  2. filtrationFiltration of the crystals
  3. customdrying at 85° C. for 3 hours

Sources & evidence

ORD record
ord-d3a2f401e2864739b4f87bb23cf02551
Source dataset
uspto-grants-1999_11
Patent number
US05985864

Reaction notes

Loading…