4-Hydroxymethylpyridine → HCID 15462314, compound

HRID 1602878Notes

Reaction equation

HRID 1602878 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1.C([O:12][CH:13]([CH3:26])[CH2:14][CH2:15][C:16]1[CH:21]=[C:20](Cl)[N:19]2[N:23]=[CH:24][CH:25]=[C:18]2[N:17]=1)(=O)C.[H-].[Na+]>CN(C=O)C>[OH:12][CH:13]([CH3:26])[CH2:14][CH2:15][C:16]1[CH:21]=[C:20]([O:1][CH2:2][C:3]2[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=2)[N:19]2[N:23]=[CH:24][CH:25]=[C:18]2[N:17]=1

Participants

5

Reactant 3

HCID 114724-HydroxymethylpyridineHCID 24758Sodium hydrideHCID 19608373HCID 19608373, compound

Product 1

HCID 15462314HCID 15462314, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The procedure of Example 1 was followed except using 340 mg of 4-(hydroxymethyl)pyridine, 280 mg of 5-(3-acetoxybutyl)-7-chloropyrazolo[1,5-a]pyrimidine and 105 mg of 60% sodium hydride and using DMF as a solvent. The title compound was obtained as colorless crystals (50 mg). The structure and melting point of the compound obtained are shown in Table 1.

Sources & evidence

ORD record
ord-74119cc160b94115a58105b661a2f231
Source dataset
uspto-grants-1999_11
Patent number
US05985882

Reaction notes

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