反应详情

32 mg of copper iodide and 140 mg of bis(triphenylphosphine) palladium chloride, then 2.3 ml of 1-hexyne were added to a solution of 4.4 g of 2-iodoaniline in 100 ml of triethylamine and the mixture was stirred for 15 hours at ambient temperature. After evaporation to dryness, the residue was taken up in ether and the insoluble part was filtered out and washed with ether. The filtrate was evaporated to dryness and the residue was chromatographed on silica (eluant: hexane-ethyl acetate (9-1)) to obtain 3.27 g of the desired product.

1. customAfter evaporation to dryness
2. filtrationthe insoluble part was filtered out
3. washwashed with ether
4. customThe filtrate was evaporated to dryness
5. customthe residue was chromatographed on silica (eluant: hexane-ethyl acetate (9-1))