Hydrochloric Acid → HCID 14358601, compound

HRID 1603262Notes

Reaction equation

HRID 1603262 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:5]([C:6]([OH:8])=[O:7])[C:4]=1[C:12]([OH:14])=[O:13].Cl.[CH3:16]O>O.CO.Cl[Cu]>[CH3:16][O:7][C:6](=[O:8])[C:5]1[C:4](=[C:3]([O:2][CH3:1])[CH:11]=[CH:10][CH:9]=1)[C:12]([OH:14])=[O:13]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3152183-Methoxyphthalic acid

Product 1

HCID 14358601HCID 14358601, compoundYield 63%

Reagents, catalysts & solvents 2

HCID 62652Cuprous chlorideCatalystHCID 22242641Methanol--water (1/1)Solvent

Procedure

A solution of methoxyphthalic acid obtained as per Example 5 (0.1 mol) in 100 ml methanol was added with CuCl (0.1 mol) and HCl (0.1 mol). The solution was heated to reflux for 30 min. The clear solution obtained was evaporated to dryness under reduced pressure. The residue obtained was dissolved in a 1:3 water-methanol mixture and acidified. The product was separated by cooling, collected by filtration and air dried. The product yield was 63-66%.

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux for 30 min
  3. customThe clear solution obtained
  4. customwas evaporated to dryness under reduced pressure
  5. customThe residue obtained
  6. customThe product was separated
  7. temperatureby cooling
  8. filtrationcollected by filtration and air
  9. customdried

Sources & evidence

ORD record
ord-a1929e08259e417fab59255c4b625ba9
Source dataset
uspto-grants-1999_11
Patent number
US05986129

Reaction notes

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