Allyl Alcohol → 4-allyloxycarbonylamino-2-(N-t-butoxycarbonylamino)methylthiazole

Temperature

90 °C

To a mixed solution obtained by adding 2.74 ml of triethylamine to 210 ml of a dry THF solution containing 4.228 g of 2-(N-t-butoxycarbonylamino)methylthiazol-4-carboxylic acid, 1.94 ml of ethyl chloroformate was added dropwise at -12° C. over 2 minutes under stirring, and the mixture was then stirred at the same temperature for 120 minutes. Further, 50 ml of a cold aqueous solution containing 1.316 g of sodium azide was added thereto, followed by stirring at 2° C. for 140 minutes. Afterward, the reaction solution was concentrated under reduced pressure until the amount of the solution had been halved. The solution was diluted with 300 ml of ethyl acetate, washed with water, and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to obtain a colorless powder, and this powder was then dissolved in 200 ml of dry toluene. Then, 3.34 ml of dry allyl alcohol was further added, and the mixed solution was heated at an oil temperature of 90° C. for 3 hours with stirring. Afterward, the solvent was evaporated under reduced pressure to obtain an oil, and this oil was then dissolved in 400 ml of ethyl acetate. The solution was washed with water and then dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to obtain 4.791 g of 4-allyloxycarbonylamino-2-(N-t-butoxycarbonylamino)methylthiazole as an orange oil.

1. customTo a mixed solution obtained
2. additionwas added dropwise at -12° C. over 2 minutes
3. stirringthe mixture was then stirred at the same temperature for 120 minutes
4. additionwas added
5. stirringby stirring at 2° C. for 140 minutes
6. concentrationAfterward, the reaction solution was concentrated under reduced pressure until the amount of the solution
7. additionThe solution was diluted with 300 ml of ethyl acetate
8. washwashed with water
9. dry with materialdried over anhydrous magnesium sulfate
10. customThe solvent was evaporated under reduced pressure
11. customto obtain a colorless powder
12. stirringwith stirring
13. customAfterward, the solvent was evaporated under reduced pressure
14. customto obtain an oil
15. washThe solution was washed with water
16. dry with materialdried over anhydrous magnesium sulfate
17. customthe solvent was evaporated under reduced pressure

ORD record

ord-c8ef4d49ff1f4632961e74343306f44e

Source dataset

uspto-grants-1999_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05990101