反应详情

A mixture of 5-nitroindole (0.49 g, 3 mmol), 3-bromopyridine (0.95 g, 6 mmol), copper (I) bromide (60 mg, 0.42 mmol) and potassium carbonate (0.62 g, 4.5 mmol) in pyridine (2 mL) and nitrobenzene (0.6 mL) was heated under reflux for 4 h. After cooling, the mixture was diluted with water and extracted with ethyl acetate. The organic extract was washed with water, dried and evaporated. The residue was chromatographed on silica gel eluted with ethyl acetate to give the tide compound (0.62 g, 86.5%), mp. 164-5° C.

1. temperaturewas heated
2. temperatureunder reflux for 4 h
3. temperatureAfter cooling
4. extractionextracted with ethyl acetate
5. extractionThe organic extract
6. washwas washed with water
7. customdried
8. customevaporated
9. customThe residue was chromatographed on silica gel
10. washeluted with ethyl acetate