HRID1603877

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7268

Diethyl oxalate

C6H10O4

结构：CC(=O)c1cccc(NC(=O)c2ccc3c(c2)CCC(COCc2ccccc2)O3)c1O

HCID19606371

未命名化合物

PRODUCTS

生成物

HCID8857

Ethyl acetate

C4H8O2

收率 66%

结构：CCOC(=O)c1cc(=O)c2cccc(NC(=O)c3ccc4c(c3)CCC(COCc3ccccc3)O4)c2o1

HCID19606281

未命名化合物

PROCEDURE

实验过程

Following the process described at point A, starting from N-(3-acetyl-2-hydroxyphenyl)-2-(benzyloxymethyl)chromane-6-carboxamide and diethyl oxalate, the title compound was prepared, which was purified by warm crystallization in ethyl acetate (66% yield).

WORKUP

后处理

customwhich was purified
temperatureby warm

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9f384bd90a66428b87d2d2bab5374246
来源数据集: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05990142
来源说明: uspto-grants-1999_11

反应 SMILES

[C:1]([C:4]1[C:5]([OH:32])=[C:6]([NH:10][C:11]([C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[O:19][CH:18]([CH2:23][O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:17][CH2:16]3)=[O:12])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].[C:33](OCC)(=O)[C:34]([O:36][CH2:37][CH3:38])=[O:35]>>[CH2:25]([O:24][CH2:23][CH:18]1[CH2:17][CH2:16][C:15]2[C:20](=[CH:21][CH:22]=[C:13]([C:11]([NH:10][C:6]3[C:5]4[O:32][C:33]([C:34]([O:36][CH2:37][CH3:38])=[O:35])=[CH:2][C:1](=[O:3])[C:4]=4[CH:9]=[CH:8][CH:7]=3)=[O:12])[CH:14]=2)[O:19]1)[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1.[C:34]([O:36][CH2:37][CH3:38])(=[O:35])[CH3:33]