Hydrochloric Acid → HCID 15429170, compound

HRID 1603951Notes

Reaction equation

HRID 1603951 reaction equation
[CH3:1][C:2](C)([O:4]C([N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([NH:21][C:22]3[CH:34]=[CH:33][C:25]([O:26][CH2:27][C:28]([O:30]CC)=[O:29])=[C:24]([N+:35]([O-:37])=[O:36])[CH:23]=3)=[O:20])=[CH:15][CH:14]=2)[CH2:9][CH2:8]1)=O)C.Cl.[OH:40][Li].O>CCOC(C)=O>[N:10]1([C:13]2[CH:18]=[CH:17][C:16]([C:19]([NH:21][C:22]3[CH:34]=[CH:33][C:25]([O:26][CH2:27][C:28]([OH:30])=[O:29])=[C:24]([N+:35]([O-:37])=[O:36])[CH:23]=3)=[O:20])=[CH:15][CH:14]=2)[CH2:11][CH2:12][NH:7][CH2:8][CH2:9]1.[CH3:1][CH2:2][OH:4].[OH2:40].[NH4+:7].[OH-:4]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 19605577HCID 19605577, compound

Product 2

HCID 15429170HCID 15429170, compoundHCID 86596525Ethanol ammonium hydroxide water

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 5-9 (0.186 g, 0.352 mmol) in EtOAc was treated first with HCl gas then with LiOH.H2O as described for 5-6 to give 5-10 as a yellow solid after chromatography in 18:1:1 EtOH/H2O/NH4OH).

Sources & evidence

ORD record
ord-97658b6085ec4832ae8db13606f54b33
Source dataset
uspto-grants-1999_11
Patent number
US05990107

Reaction notes

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