Hydrochloric Acid → HCID 19603751, compound

HRID 1604651Notes

Reaction equation

HRID 1604651 reaction equation
[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([CH2:19][C:20]#[N:21])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].C(N)(=[S:24])C.Cl.O1CCOCC1>C(Cl)(Cl)Cl>[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([CH2:19][C:20](=[S:24])[NH2:21])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 2723949ThioacetamideHCID 19603837HCID 19603837, compound

Product 1

HCID 19603751HCID 19603751, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A mixture of 4-tert-butyl-2-[5-(cyanomethyl)benzofuran-2-yl]thiazole (1.31 g) and thioacetamide in a mixture of 4N-hydrogen chloride of 1,4-dioxane (4 ml) and chloroform was stirred under reflux for 30 minutes and removed the solvent at the same temperature. The residue was washed with water to give crude 4-tert-butyl-2-[5-(thiocarbamoylmethyl)-benzofuran-2-yl]thiazole (1.23 g).

Workup

  1. temperatureunder reflux for 30 minutes
  2. customremoved the solvent at the same temperature
  3. washThe residue was washed with water

Sources & evidence

ORD record
ord-69ee25559fc64d9c8336fff485e37bec
Source dataset
uspto-grants-1999_11
Patent number
US05994378

Reaction notes

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