Methyl iodide → HCID 21400841, compound

HRID 1605023Notes

Reaction equation

HRID 1605023 reaction equation
[C:1]([C:5]1[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=1[C:11]1[CH:15]=[C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[NH:13][N:12]=1)([O:3][CH3:4])=[O:2].[H-].[Na+].[CH3:24]I>O1CCCC1>[CH3:24][N:13]1[C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:15][C:11]([C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:5]=2[C:1]([O:3][CH3:4])=[O:2])=[N:12]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 178496910HCID 178496910, compound

Product 1

HCID 21400841HCID 21400841, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 3.0 g 3-(2-carbomethoxy-1-cyclohexen-1-yl)-5-phenylpyrazole, 0.3 g of 50% sodium hydride-mineral oil slurry, and 1.0 g of methyl iodide in 50 ml of anhydrous tetrahydrofuran is stirred and refluxed overnite. The reaction mixture is filtered, and the solvent is evaporated from the filtrate to give 1-methyl-3-(2-carbomethoxy-1-cyclohexen-1-yl)-5-phenylpyrazole.

Workup

  1. temperaturerefluxed overnite
  2. filtrationThe reaction mixture is filtered
  3. customthe solvent is evaporated from the filtrate

Sources & evidence

ORD record
ord-2edb842c44e94845bc27fbec4ad0e9a5
Source dataset
uspto-grants-1976_04
Patent number
US03948937

Reaction notes

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