Hydrochloric Acid → HCID 12800574, compound

HRID 1605399Notes

Reaction equation

HRID 1605399 reaction equation
[CH3:1][C:2]([O:4][CH2:5][C:6]1[CH2:23][S:22][C@@H:9]2[C@H:10]([NH:13][C:14]([CH2:16][C:17]3[S:21][CH:20]=[CH:19][CH:18]=3)=[O:15])[C:11](=[O:12])[N:8]2[C:7]=1[C:24]([O-:26])=[O:25])=[O:3].[Na+].C(OCC)(=O)C.Cl>O>[C:2]([O:4][CH2:5][C:6]1[CH2:23][S:22][C@@H:9]2[CH:10]([NH:13][C:14](=[O:15])[CH2:16][C:17]3[S:21][CH:20]=[CH:19][CH:18]=3)[C:11](=[O:12])[N:8]2[C:7]=1[C:24]([OH:26])=[O:25])(=[O:3])[CH3:1]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 23675321Cephalothin Sodium

Product 1

HCID 12800574HCID 12800574, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

21.6 g of sodium cephalothin was dissolved in 500 ml of water and layered with 500 ml ethyl acetate. The mixture was acidified to pH4 by addition of 6N HCl and the product was extracted into the ethyl acetate phase, which was dried (MgSO4) and evaporated in vacuo to yield 20.4 g of 3-acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid, mp 152°-154°.

Workup

  1. extractionthe product was extracted into the ethyl acetate phase, which
  2. dry with materialwas dried (MgSO4)
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-7e56421309f445689b11c7a2e536f2b7
Source dataset
uspto-grants-1976_04
Patent number
US03950329

Reaction notes

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