Triethylamine → HCID 12968719, compound

HRID 1605825Notes

Reaction equation

HRID 1605825 reaction equation
[C:1]([NH:11][CH2:12][C:13]([OH:15])=[O:14])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].[Cl:16][CH2:17]I.C(N(CC)CC)C>CN(C=O)C>[Cl:16][CH2:17][O:14][C:13](=[O:15])[CH2:12][NH:11][C:1]([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 11644ChloroiodomethaneHCID 14349Benzyloxycarbonylglycine

Product 1

HCID 12968719HCID 12968719, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of N-carbobenzoxy-glycine (4.2 g), chloroiodomethane (6.0 ml), and triethylamine (3.5 ml) in DMF (10 ml) was stirred for 2 hours at room temperature. The mixture was worked up and purified in the same way as described in Example 6A to yield the desired compound as a slightly yellowish oil.

Workup

  1. custompurified in the same way

Sources & evidence

ORD record
ord-793c0a5b54564f8cbca2c36e6e21911f
Source dataset
uspto-grants-1976_04
Patent number
US03951957

Reaction notes

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