反应详情

A mixture of 4.8 g. 3-propylsulphinyl-1,2,4-triazole, 4.48 g. diethylcarbamoyl chloride, 40 ml. dry tetrahydrofuran and 6 ml. dry triethylamine was refluxed under anhydrous conditions for 5 hours. The cooled reaction mixture was filtered to remove triethylamine hydrochloride. The filtrate was diluted with petroleum ether (b.p. 40° - 60°C.), causing the deposition of an oil which gradually solidified. The solid product was collected and recrystallized from a mixture of ether and petroleum ether (b.p. 40° - 60°C.) to give 1-diethylcarbamoyl-3-propylsulphinyl-1,2,4-triazole, m.p. 50.5° - 51.5°C.

1. additionA mixture of 4.8 g
2. customThe cooled reaction mixture
3. filtrationwas filtered
4. customto remove triethylamine hydrochloride
5. additionThe filtrate was diluted with petroleum ether (b.p. 40° - 60°C.)
6. customThe solid product was collected
7. customrecrystallized from a mixture of ether and petroleum ether (b.p. 40° - 60°C.)