Hydrochloric Acid → HCID 13186853, compound

HRID 1607372Notes

Reaction equation

HRID 1607372 reaction equation
[N+:1]([CH:4]([CH3:6])[CH3:5])([O-:3])=[O:2].[CH3:7][O:8][CH2:9][CH2:10][C:11]1[CH:20]=[CH:19][C:14]([O:15][CH2:16][CH:17]=[O:18])=[CH:13][CH:12]=1.[Na].Cl>CO>[CH3:7][O:8][CH2:9][CH2:10][C:11]1[CH:20]=[CH:19][C:14]([O:15][CH2:16][CH:17]([OH:18])[C:4]([N+:1]([O-:3])=[O:2])([CH3:6])[CH3:5])=[CH:13][CH:12]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3982-NitropropaneHCID 5360545SodiumHCID 11830305HCID 11830305, compound

Product 1

HCID 13186853HCID 13186853, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

39.5 g of 2-nitropropane and 27 g of 4-(2-methoxyethyl)-phenoxy-acetaldehyde are successively added dropwise to a solution of 2 g of sodium in 150 ml of methanol. After the mixture has been stirred at room temperature for 15 hours, the solution is poured onto water and acidified with 2N HCl. Extraction with CHCl3 gives, after crystallisation from diisopropyl ether, 23.3 g of the nitro compound mentioned in the title. Melting point: 92°-94° C.

Workup

  1. additionthe solution is poured onto water
  2. extractionExtraction with CHCl3
  3. customgives
  4. customafter crystallisation from diisopropyl ether, 23.3 g of the nitro compound

Sources & evidence

ORD record
ord-9493f517f8624ae4b4019959b8fcc708
Source dataset
uspto-grants-1989_09
Patent number
US04864061

Reaction notes

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