反应详情

Benzyl bromide (13.1 ml) was added to a stirred mixture of 2-bromo-4-chlorophenol (20.7 g) and potassium carbonate (27.6 g) in DMF (200 ml). After 72 h, the mixture was partitioned between diethylether and water, the organic layer washed with water, dried and the solvent evaporated under reduced pressure. The residue was purified by chromatography (silica, EtOAc/isohexane as eluent). to give the sub-title compound (18.1 g).

1. customthe mixture was partitioned between diethylether and water
2. washthe organic layer washed with water
3. customdried
4. customthe solvent evaporated under reduced pressure
5. customThe residue was purified by chromatography (silica, EtOAc/isohexane as eluent)