Dimethylformamide → HCID 14592965, compound

HRID 1607644Notes

Reaction equation

HRID 1607644 reaction equation
CN(C)C=O.C(=O)([O-])[O-].[K+].[K+].[CH:12](I)([CH3:14])[CH3:13].[OH:16][C:17]1[C:26]([OH:27])=[C:25]2[C:20]([C:21](=[O:30])[CH2:22][C:23]([CH3:29])([CH3:28])[O:24]2)=[CH:19][CH:18]=1>COCCOCCOC>[CH:12]([O:16][C:17]1[C:26]([OH:27])=[C:25]2[C:20]([C:21](=[O:30])[CH2:22][C:23]([CH3:28])([CH3:29])[O:24]2)=[CH:19][CH:18]=1)([CH3:14])[CH3:13]

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 6362Isopropyl iodideHCID 11430Potassium CarbonateHCID 14184035HCID 14184035, compound

Product 1

HCID 14592965HCID 14592965, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 8150DiglymeSolvent

Conditions

Temperature
140 °C

Procedure

In 50 ml of N,N-dimethyl formamide 4.2 g (20 millimoles) of 7.8-dihydroxy-2,2-dimethyl-4-chromanone are dissolved, whereupon 5 ml of diethylene glycol dimethylether, 3.0 g (22 millimoles) of potassium carbonate and 4.2 g (2.5 ml, 25 millimoles) of isopropyl iodide are added. The reaction mixture is heated at 140° C. for 4 hours and worked up according to Example 19. Thus 4.5 g of the desired compound are obtained, yield 90%, mp.: 114°-116° C.

Workup

  1. additionare added

Sources & evidence

ORD record
ord-5621387df2be4481a6a8e54729a9ffa6
Source dataset
uspto-grants-1989_09
Patent number
US04866089

Reaction notes

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