反应详情

In 100 ml of methyl-ethyl-ketone 4.45 g (20 millimoles) of 6-hydroxy-7-methoxy-2,2-dimethyl-4-chromanone are dissolved, whereupon 4.1 g (30 millimoles) of potassium carbonate and 4.7 g (2.4 ml, 30 millimoles) of ethyl iodide are added and the reaction mixture is refluxed for 5 hours. The precipitated inorganic salt is filtered off, washed twice with 20 ml of acetone each and the solvent is removed. The residue is crystallized from 90% ethanol. Thus 4.75 g of the desired compound are obtained, yield 95%. Mp.: 86°-87° C.

1. additionare added
2. temperaturethe reaction mixture is refluxed for 5 hours
3. filtrationThe precipitated inorganic salt is filtered off
4. washwashed twice with 20 ml of acetone each and the solvent
5. customis removed
6. customThe residue is crystallized from 90% ethanol