反应详情

A mixture of 3'-chloro-4'-nitroacetophenone (3 g), m-chlorophenol (2.3 g) and potassium carbonate (2.5 g) in xylene (30 ml) was stirred and refluxed for 7 hours. The insoluble was filtered and the filtrate was washed with an aqueous solution of sodium hydroxide (10%) and water, dried, and concentrated. The residue was purified by column chromatography on silica gel eluting with toluene to give an oil of 3'-(3-chlorophenoxy)-4'-nitroacetophenone (2.4 g).

1. temperaturerefluxed for 7 hours
2. filtrationThe insoluble was filtered
3. washthe filtrate was washed with an aqueous solution of sodium hydroxide (10%) and water
4. customdried
5. concentrationconcentrated
6. customThe residue was purified by column chromatography on silica gel eluting with toluene