Water → HCID 19849744, compound

HRID 1607890Notes

Reaction equation

HRID 1607890 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[O:9][CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH:33](Br)([C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1.O>C1(C)C(C)=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=2)[O:9][CH2:10][CH2:11][CH2:12][N:13]2[CH2:14][CH2:15][N:16]([CH:33]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[CH2:17][CH2:18]2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 236603BromodiphenylmethaneHCID 19849736HCID 19849736, compound

Product 1

HCID 19849744HCID 19849744, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution containing 10.4 g of 1-[3-[bis(4-fluorophenyl)methoxy]propyl]piperazine, 4.6 ml of triethylamine and 8.1 g of benzhydryl bromide in 100 ml of anhydrous xylene is refluxed for 8 hours and then cooled down. The mixture is washedwith water, dried over anhydrous magnesium sulfate and evaporated under reduced pressure. The resiude is recrystallized from n-hexane to give the aimed product, m.p.: 78°-79° C.

Workup

  1. temperatureis refluxed for 8 hours
  2. temperaturecooled down
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customevaporated under reduced pressure
  5. customThe resiude is recrystallized from n-hexane

Sources & evidence

ORD record
ord-98b0bc7707b448c195f08e3f35c62f94
Source dataset
uspto-grants-1989_09
Patent number
US04868184

Reaction notes

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