反应详情

10 g of 4-acetoxy-3,5-dibromostyrene are dissolved in 50 ml THF and 25 ml methanol, 12 g hydrazine hydrate (80% aqueous solution) is added, and the cloudy mixture is then converted into a clear solution by adding 3 ml of water. After 40 minutes it is acidified with a semi-concentrated HCl to pH2 and extracted twice with ether, the ether phase is washed twice with water and dried over sodium sulfate, and the ether is removed with a rotary evaporator at room temperature under aspirator vacuum. 8.5 g of crude product remain, from which 6.45 g of white crystals (mp 74° C.) are obtained by recrystallization from petroleum ether.

1. extractionextracted twice with ether
2. washthe ether phase is washed twice with water
3. dry with materialdried over sodium sulfate
4. customthe ether is removed with a rotary evaporator at room temperature under aspirator vacuum
5. customare obtained by recrystallization from petroleum ether