Potassium Carbonate → 3-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-6,7,8-trifluoro-, ethyl ester

HRID 1608356Notes

Reaction equation

HRID 1608356 reaction equation
C(OC(CC[NH:8][CH:9]=[C:10]([C:16](=[O:27])[C:17]1[CH:22]=[C:21]([F:23])[C:20]([F:24])=[C:19]([F:25])[C:18]=1F)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=O)C.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[F:25][C:19]1[CH:18]=[C:17]2[C:22](=[C:21]([F:23])[C:20]=1[F:24])[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:16]2[OH:27]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 178472019HCID 178472019, compound

Product 1

HCID 27339723-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-6,7,8-trifluoro-, ethyl ester

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

7.7 g of the compound from Example 6 and 2.9 g of K2CO3 are heated at 140°-5° C. for 4 hours in 36 ml of DMF. The mixture is subsequently poured onto ice and acidified, and the precipitated solid is separated off and dried. Yield: 4.5 g, melting point: 279°-82° C.

Workup

  1. additionThe mixture is subsequently poured onto ice
  2. customthe precipitated solid is separated off
  3. customdried

Sources & evidence

ORD record
ord-8053176ab59749eda6ce744e959dc7da
Source dataset
uspto-grants-1989_09
Patent number
US04870182

Reaction notes

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