Hydrochloric Acid → HCID 67803491, compound

HRID 1608670Notes

Reaction equation

HRID 1608670 reaction equation
C(CC[O:5][C:6]([C:8]1[C@H:9]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([N+:28]([O-:30])=[O:29])[CH:23]=2)[C:10]([C:16]([O:18][CH2:19][O:20][CH3:21])=[O:17])=[C:11]([CH3:15])[NH:12][C:13]=1[CH3:14])=[O:7])#N.[OH-].[Na+].O.Cl>O1CCOCC1.C(OCC)(=O)C>[CH3:14][C:13]1[NH:12][C:11]([CH3:15])=[C:10]([C:16]([O:18][CH2:19][O:20][CH3:21])=[O:17])[C@@H:9]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([N+:28]([O-:30])=[O:29])[CH:23]=2)[C:8]=1[C:6]([OH:7])=[O:5]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 86748548HCID 86748548, compound

Product 1

HCID 67803491HCID 67803491, compoundYield 82.8%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 3.6 mg of methoxymethyl (4S)-5-(2-cyanoethoxy-carbonyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3-carboxylate in 0.25 ml of dioxane was added 0.1 ml of 1N aqueous sodium hydroxide solution. The mixture was stirred at room temperature for 1 hour. The reaction mixture was diluted with 5 ml of ethyl acetate, to which were added water and 0.1 ml of 1N aqueous hydrochloric acid. The resulting mixture was dried over anhydrous Glauber's salt (sodium sulfate), followed by distilling off the solvent under reduced pressure to obtain 2.6 mg of the objective compound.

Workup

  1. dry with materialThe resulting mixture was dried over anhydrous Glauber's salt (sodium sulfate)
  2. distillationby distilling off the solvent under reduced pressure

Sources & evidence

ORD record
ord-2c31bb91344947f99d52f75b914c6ffe
Source dataset
uspto-grants-1995_03
Patent number
US05395941

Reaction notes

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