Water → HCID 455187, compound

HRID 1608782Notes

Reaction equation

HRID 1608782 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:16]=[C:17]([CH3:19])[CH:18]=1)[C:5]([C:7]1[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=O)=O.[NH2:20][CH2:21][CH2:22][SH:23].C1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1(C)C(C)=CC=CC=1>[CH3:19][C:17]1[CH:16]=[C:4]([C:5]23[S:23][CH2:22][CH2:21][N:20]2[C:9](=[O:11])[C:8]2[C:7]3=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:3]=[C:2]([CH3:1])[CH:18]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6058CysteamineHCID 6101p-Toluenesulfonic acidHCID 759249HCID 759249, compound

Product 1

HCID 455187HCID 455187, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

10 mmol 2-(3,5-dimethylbenzoyl)-benzoic acid were dissolved in 100 ml of xylene and, after addition of 20 mmol cysteamine, as well as a catalytic amount of p-toluenesulphonic acid, heated for 2 h under reflux on a water separator. The solvent was then removed in a vacuum and the residue recrystallised from ethanol. Yield 53%, m.p. 163° C.

Workup

  1. customThe solvent was then removed in a vacuum
  2. customthe residue recrystallised from ethanol

Sources & evidence

ORD record
ord-20280122556b44cba089d43b03ae0235
Source dataset
uspto-grants-1995_03
Patent number
US05397794

Reaction notes

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